In order to resist the targeted intelligent interference attack in wireless sensor networks, this paper proposes an anti-jamming attack method based on hybrid frequency hopping spread spectrum, uncoordinated direct sequence spread spectrum and uncoordinated frequency hopping spread spectrum based on multiple spread spectrum techniques. In order to solve the limitation of sharing key in advance in traditional spread spectrum technology, uncoordinated frequency hopping spread spectrum is used for network communication in the initial stage of the network. In order to avoid the high energy consumption caused by the continuous use of uncoordinated spread spectrum frequency hopping, the nodes of both sides of communication generate frequency hopping sequence in uncoordinated spread spectrum hopping mode and then transfer to traditional frequency hopping spread spectrum communication. The performance of anti-jamming attack is further enhanced by uncoordinated direct sequence spread spectrum technology. Using OPNET and network simulation based on multiple interference attack models, the effectiveness of the proposed hybrid anti-interference attack method is verified. The simulation results show that the proposed hybrid anti-interference attack method can effectively resist interference attacks in wireless sensor networks because the network can still maintain a low packet loss rate when it is attacked by strong targeted intelligent interference attacks.