Abstract: The problem of channel estimation in multiple input multiple output orthogonal frequency division multiplexing with offset quadrature amplitude modulation (MIMO-OFDM/OQAM) systems is considered. The general preamble based time domain channel estimation model is proposed and the frequency domain pilots are used to estimate the time domain channel impulse responses. Different from the conventional methods, this method needs fewer pilots overhead and has better estimation performance for highly frequency selective channels. Theoretical analyses and simulation results show the effectiveness of the proposed method.